Nanoparticles laden in situ gelling system for ocular drug targeting

in situ gelling systems for drug delivery

In Situ Gelling Systems for Drug Delivery

Implication for health policy/practice/research/medical education: Development of polymeric in situ gels for controlled release of various drugs provides a number of advantages over conventional dosage forms. Some important advantages of these smart systems are ease of application and reduced frequency of administration, as well as protection of the drug from environmental conditions. Published...

Hp-β-CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

The objective of the present study was to design ophthalmic delivery systems based on polymeric carriers that undergo sol-to-gel transition upon change in temperature or in the presence of cations so as to prolong the effect of HP- β -CD Voriconazole (VCZ) in situ gelling formulations. The in situ gelling formulations of Voriconazole were prepared by using pluronic F-127 (PF-127) or with combin...

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Submit Manuscript | http://medcraveonline.com Abbreviations: HPMC: Hydroxypropyl Methylcellulose; MC: Methylcellulose; PLGA: Poly (Lactide-co-Glycolide); CAP: Cellulose Acetate Phthalate; LCST: Low Critical Solution Temperature; UCST: Upper Critical Solution Temperature; PPO: Polypropylene Oxide; PEO: Polyethylene Oxide; MTA: Methozolamide; PNIPAAm: Poly (N-Isopropylacrylamide); GC: Guluronic A...

Design of Polyoxyethylene-polyoxypropylene Block Co- Polymer Based in Situ Gelling System for Localized Ocular Drug Delivery

Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The timely gelation and retention of in situ-gelling ophthalmic formulations would be fundamental to improve the efficacy of drugs. The aim of this investigation was to develop ocular drug delivery system with simplicity in installation for patient...